The Milwaukee Brewers wrap up their Sunday afternoon slate at American Family Field on September 27, 2026, hosting the St. Louis Cardinals in a late-season NL Central matchup with first pitch scheduled for 3:10 PM ET. Right-hander Jacob Misiorowski gets the ball for Milwaukee against Cardinals starter Andre Pallante. With the regular season winding down, every game carries weight in the standings, and this division rivalry gives the Brewers a chance to close things out strong in front of their home crowd.
Probable Pitching Matchup: Misiorowski vs. Pallante
Jacob Misiorowski takes the mound for Milwaukee in what shapes up as a pivotal late-season assignment. The young right-hander has shown flashes of the stuff that made him one of the more intriguing arms in the Brewers system — a lively fastball and a breaking ball that can be genuinely difficult to square up when he is locating consistently. The key question Sunday is whether he can go deep into the game and keep the Cardinals' lineup off-balance from pitch one.
Andre Pallante gets the nod for St. Louis. The Cardinals right-hander is the kind of pitcher who lives off contact management and changing hitter eye levels. He does not overpower lineups, but he can be effective when his sinker is working and he is getting quick outs early in counts. Brewers hitters will need to grind at-bats and avoid the early-count pop-up and soft-contact game that Pallante is built to induce.
Keys to Watch for the Brewers
- Misiorowski's command: When he is throwing strikes early in counts, he is a different pitcher. Walk trouble or falling behind hitters could shorten his outing and tax a bullpen that has been leaned on heavily this season.
- Plate discipline against Pallante: Pallante works to get hitters to chase and hit the ball on the ground. Patient at-bats and working deep into counts will be essential for Milwaukee's offense to do damage.
- Bullpen management: If Misiorowski exits before the sixth inning, how Pat Murphy deploys his relief corps in a divisional game with standings implications will be worth watching closely.
- Capitalizing at home: American Family Field has been a genuine advantage for the Brewers this season, and the home crowd on a Sunday afternoon can be a real factor in close, low-scoring games like the ones Pallante tends to produce.
Prediction
This looks like a tight, gritty game — exactly the kind of afternoon contest that comes down to a two-out hit or a big strikeout in the sixth inning. Pallante will keep the Brewers honest, but if Misiorowski is on, Milwaukee has the edge at home. Expect a competitive game that stays within two runs deep into the late innings. Give the Brewers the edge in a 3-2 final, with the bullpen closing it out at American Family Field.
Catch the game on Brewers.TV Presented by Potawatomi Sportsbook or on WTMJ 620 AM locally. Cardinals fans can tune in on Cardinals.TV Presented by bet365 or KMOX 1120 AM/104.1 FM.
