The Milwaukee Brewers wrap up a regular season home contest against the St. Louis Cardinals on Sunday, September 27, 2026, at American Family Field. First pitch is scheduled for 3:10 PM ET, with Jacob Misiorowski getting the ball for Milwaukee opposite St. Louis right-hander Andre Pallante. With the calendar winding down toward the end of the regular season, every game carries real weight, and a division rivalry matchup like this one is never just a formality — not when the Cardinals are coming to town.

Probable Pitchers: Misiorowski vs. Pallante

Jacob Misiorowski draws the start for the Brewers, and the young right-hander has shown the kind of raw stuff that makes him worth watching every time he takes the ball. His fastball-slider combination gives hitters fits, and in a late-season spot start with playoff implications potentially lurking in the background, this is exactly the moment a young arm can define itself.

Andre Pallante gets the call for St. Louis. The Cardinals right-hander is a contact-inducing, ground-ball-heavy pitcher who works efficiently and rarely beats himself with walks. He is the kind of pitcher who can neutralize a lineup if his defense plays behind him cleanly. Milwaukee's offense will need to be disciplined and look to work counts against him rather than chase early in the at-bat.

Milwaukee Brewers Starting Lineup

• Garrett Mitchell — CF
• Jake Bauers — 1B
• Jackson Chourio — LF
• Brice Turang — 2B
• Gary Sánchez — C
• Christian Yelich — DH
• Cooper Pratt — SS
• Sal Frelick — RF
• David Hamilton — 3B

St. Louis Cardinals Starting Lineup

• Jordan Walker — RF
• Iván Herrera — DH
• Leo Bernal — 1B
• Nolan Gorman — 3B
• Thomas Saggese — SS
• Nathan Church — CF
• José Fermín — LF
• César Prieto — 2B
• Pedro Pagés — C

Keys to Watch at American Family Field

Jackson Chourio in the Middle of the Order

Batting third, Chourio is the Brewers' most dynamic offensive weapon in this lineup. He has the combination of power and athleticism that can change a game in a single at-bat. If Pallante tries to work him away with his ground-ball approach, Chourio has shown the ability to go the other way with authority. He is the name to watch on the Milwaukee side.

Nolan Gorman's Power Threat

Batting cleanup for St. Louis, Gorman is a legitimate power hitter who can hurt you in a hurry. Misiorowski will need to be careful not to leave pitches elevated in the zone when Gorman steps in. One mistake can turn a close game in an instant, and that is the kind of thing that stings late in the season.

Garrett Mitchell Setting the Table

Mitchell leads off for Milwaukee, and his ability to get on base and use his speed puts immediate pressure on the Cardinals. If Mitchell gets on and Bauers works a quality at-bat behind him, this Brewers lineup can score before the middle of the order even comes to the plate.

Prediction

This shakes out as a tight, low-scoring game — the kind that Pallante tends to produce. But Misiorowski has the ceiling to match him pitch for pitch, and American Family Field gives Milwaukee a genuine edge. Give the Brewers a 4-2 win on the strength of Misiorowski's stuff and a Chourio extra-base hit that does the damage. Brewers take it at home.