The Milwaukee Brewers head to Oriole Park at Camden Yards on Sunday, September 20, 2026, for a 7:20 PM ET clash with the Baltimore Orioles. Jacob Misiorowski takes the ball for Milwaukee against Baltimore's Brandon Young in what shapes up as a compelling late-season interleague matchup. The game airs on Peacock/NBCSN and can be heard locally on WTMJ 620 AM. With the regular season winding down, every game carries weight, and the Brewers need a strong road performance to keep momentum on their side.

Brewers vs. Orioles Pitching Matchup: Misiorowski vs. Young

Jacob Misiorowski gets the nod for Milwaukee and the right-hander will be tested immediately by a dangerous Baltimore lineup. Misiorowski has been one of the more intriguing arms in the Brewers system, and a national stage on Sunday night is exactly the kind of moment that defines a young pitcher's season. Baltimore counters with Brandon Young, who will look to keep Milwaukee's lineup off-balance at a ballpark that tends to play well for pitchers who keep the ball in the yard.

Keys to Watch for Milwaukee

Can the Brewers Offense Solve Young?

Milwaukee is sending out a lineup with plenty of recognizable names. Jackson Chourio leads off in left field, providing speed and athleticism at the top of the order. Brice Turang bats second, followed by William Contreras — one of the Brewers' most consistent offensive contributors — hitting third. Jake Bauers slots in at cleanup with Joey Ortiz right behind him at five. Christian Yelich, hitting sixth as the designated hitter, remains a threat to put a ball in the seats any time he steps in the box. Cooper Pratt, Garrett Mitchell, and Sal Frelick round out the bottom third.

Baltimore's Lineup Poses Real Challenges

The Orioles are no pushover offensively. Gunnar Henderson hits third for Baltimore and is one of the most dynamic young shortstops in the American League. Pete Alonso bats second at first base, bringing genuine power to the middle of the order. Coby Mayo hits cleanup at third base, and Samuel Basallo gets the DH spot at five. Misiorowski will need to locate his pitches carefully — this lineup does not give away at-bats.

• Misiorowski's command: His ability to throw strikes without leaving pitches in hittable zones will determine how deep Milwaukee can keep this game close.
• Contreras and Yelich vs. Young: If those two bats get going, the Brewers have a real chance to put runs on the board early.
• Bottom of the order production: Mitchell and Frelick have the ability to manufacture runs. Getting something from spots eight and nine would take pressure off the middle of the lineup.
• Bullpen management: A road Sunday night game means managing arms carefully. The Brewers' relief options behind Misiorowski will matter if he exits early.

Prediction

This is a winnable game for Milwaukee, but it won't be easy. Oriole Park is a tough environment, and Baltimore's lineup — anchored by Henderson and Alonso — can do damage in a hurry. Misiorowski has the stuff to keep this game competitive into the middle innings. If Contreras and Yelich can produce against Young and the Brewers' bullpen holds late, Milwaukee has a path to a road win. Brewers 4, Orioles 3.